George Nicholson

Computational biostatistics, machine learning, precision medicine

I’m a postdoc in Chris Holmes’ research group interested in the development and application of statistical methods for replicable scientific discovery in biomedicine. The data we focus on are typically complex and high-dimensional, comprising a combination of genetic, molecular and clinical data collected in large cohorts. Some methodological areas of current interest include Bayesian sparse factor models, ensemble methods in multi-view learning, and identification of responder subgroups in clinical trials.

Publications

2021

• F. Falck , H. Zhang , M. Willetts , G. Nicholson , C. Yau , C. Holmes , Multi-Facet Clustering Variational Autoencoders, Advances in Neural Information Processing Systems, 2021.
  
  @article{falck2021mfcvae,
    title = {Multi-Facet Clustering Variational Autoencoders},
    author = {Falck, Fabian and Zhang, Haoting and Willetts, Matthew and Nicholson, George and Yau, Christopher and Holmes, Chris},
    journal = {Advances in Neural Information Processing Systems},
    year = {2021}
  }
  

2017

• G. Nicholson , C. C. Holmes , A note on statistical repeatability and study design for high-throughput assays, Statistics in medicine, vol. 36, no. 5, 790–798, 2017.
  

  @article{nicholson2017note,
    title = {A note on statistical repeatability and study design for high-throughput assays},
    author = {Nicholson, George and Holmes, Chris C.},
    journal = {Statistics in medicine},
    volume = {36},
    number = {5},
    pages = {790--798},
    year = {2017},
    publisher = {John Wiley \& Sons, Ltd}
  }
  

• I. Roxanis , R. Colling , E. A. Rakha , A. Green , J. Rittscher , R. C. Conceicao , A. Ross , G. Nicholson , C. C. Holmes , Digital Analysis of Tumour Microarchitecture as an Independent Prognostic Tool in Breast Cancer, in LABORATORY INVESTIGATION, 2017, vol. 97, 68A–68A.
  

  @inproceedings{roxanis2017digital,
    title = {Digital Analysis of Tumour Microarchitecture as an Independent Prognostic Tool in Breast Cancer},
    author = {Roxanis, Ioannis and Colling, Richard and Rakha, Emad A and Green, Andrew and Rittscher, Jens and Conceicao, Raquel C and Ross, Aidan and Nicholson, George and Holmes, Chris C.},
    booktitle = {LABORATORY INVESTIGATION},
    volume = {97},
    pages = {68A--68A},
    year = {2017},
    organization = {NATURE PUBLISHING GROUP 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA}
  }
  

2015

• M. H. Angelis , G. Nicholson , M. Selloum , J. K. White , H. Morgan , R. Ramirez-Solis , T. Sorg , S. Wells , H. Fuchs , M. Fray , . others , Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics, Nature genetics, vol. 47, no. 9, 969–978, 2015.
  

  @article{de2015analysis,
    title = {Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics},
    author = {de Angelis, Martin Hrab{\v{e}} and Nicholson, George and Selloum, Mohammed and White, Jacqueline K and Morgan, Hugh and Ramirez-Solis, Ramiro and Sorg, Tania and Wells, Sara and Fuchs, Helmut and Fray, Martin and others},
    journal = {Nature genetics},
    volume = {47},
    number = {9},
    pages = {969--978},
    year = {2015},
    publisher = {Nature Publishing Group}
  }
  

2014

• K. E. Pinnick , G. Nicholson , K. N. Manolopoulos , S. E. McQuaid , P. Valet , K. N. Frayn , N. Denton , J. L. Min , K. T. Zondervan , J. Fleckner , . others , Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications, Diabetes, DB_140385, 2014.
  

  @article{pinnick2014distinct,
    title = {Distinct developmental profile of lower-body adipose tissue defines resistance against obesity-associated metabolic complications},
    author = {Pinnick, Katherine E and Nicholson, George and Manolopoulos, Konstantinos N and McQuaid, Siobh{\'a}n E and Valet, Philippe and Frayn, Keith N and Denton, Nathan and Min, Josine L and Zondervan, Krina T and Fleckner, Jan and others},
    journal = {Diabetes},
    pages = {DB\_140385},
    year = {2014},
    publisher = {American Diabetes Association}
  }
  

2012

• J. L. Min , G. Nicholson , I. Halgrimsdottir , K. Almstrup , A. Petri , A. Barrett , M. Travers , N. W. Rayner , R. Mägi , F. H. Pettersson , . others , Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes, PLoS Genet, vol. 8, no. 2, e1002505, 2012.
  

  @article{min2012coexpression,
    title = {Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes},
    author = {Min, Josine L and Nicholson, George and Halgrimsdottir, Ingileif and Almstrup, Kristian and Petri, Andreas and Barrett, Amy and Travers, Mary and Rayner, Nigel W and M{\"a}gi, Reedik and Pettersson, Fredrik H and others},
    journal = {PLoS Genet},
    volume = {8},
    number = {2},
    pages = {e1002505},
    year = {2012},
    publisher = {Public Library of Science}
  }
  

2011

• G. Nicholson , M. Rantalainen , J. V. Li , A. D. Maher , D. Malmodin , K. R. Ahmadi , J. H. Faber , A. Barrett , J. L. Min , N. W. Rayner , . others , A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection, PLoS genetics, vol. 7, no. 9, e1002270, 2011.
  

  @article{nicholson2011genome,
    title = {A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection},
    author = {Nicholson, George and Rantalainen, Mattias and Li, Jia V and Maher, Anthony D and Malmodin, Daniel and Ahmadi, Kourosh R and Faber, Johan H and Barrett, Amy and Min, Josine L and Rayner, N William and others},
    journal = {PLoS genetics},
    volume = {7},
    number = {9},
    pages = {e1002270},
    year = {2011},
    publisher = {Public Library of Science}
  }
  

• B. S. Kato , G. Nicholson , M. Neiman , M. Rantalainen , C. C. Holmes , A. Barrett , M. Uhlén , P. Nilsson , T. D. Spector , J. M. Schwenk , Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model, Proteome science, vol. 9, no. 1, 73, 2011.
  

  @article{kato2011variance,
    title = {Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model},
    author = {Kato, Bernet S and Nicholson, George and Neiman, Maja and Rantalainen, Mattias and Holmes, Chris C and Barrett, Amy and Uhl{\'e}n, Mathias and Nilsson, Peter and Spector, Tim D and Schwenk, Jochen M},
    journal = {Proteome science},
    volume = {9},
    number = {1},
    pages = {73},
    year = {2011},
    publisher = {BioMed Central}
  }
  

• M. Rantalainen , B. M. Herrera , G. Nicholson , R. Bowden , Q. F. Wills , J. L. Min , M. J. Neville , A. Barrett , M. Allen , N. W. Rayner , . others , MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven, PloS one, vol. 6, no. 11, e27338, 2011.
  

  @article{rantalainen2011microrna,
    title = {MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven},
    author = {Rantalainen, Mattias and Herrera, Blanca M and Nicholson, George and Bowden, Rory and Wills, Quin F and Min, Josine L and Neville, Matt J and Barrett, Amy and Allen, Maxine and Rayner, Nigel W and others},
    journal = {PloS one},
    volume = {6},
    number = {11},
    pages = {e27338},
    year = {2011},
    publisher = {Public Library of Science}
  }
  

• G. Nicholson , M. Rantalainen , A. D. Maher , J. V. Li , D. Malmodin , K. R. Ahmadi , J. H. Faber , I. B. Hallgrı́msdóttir , A. Barrett , H. Toft , . others , Human metabolic profiles are stably controlled by genetic and environmental variation, Molecular systems biology, vol. 7, no. 1, 525, 2011.
  

  @article{nicholson2011human,
    title = {Human metabolic profiles are stably controlled by genetic and environmental variation},
    author = {Nicholson, George and Rantalainen, Mattias and Maher, Anthony D and Li, Jia V and Malmodin, Daniel and Ahmadi, Kourosh R and Faber, Johan H and Hallgr{\'\i}msd{\'o}ttir, Ingileif B and Barrett, Amy and Toft, Henrik and others},
    journal = {Molecular systems biology},
    volume = {7},
    number = {1},
    pages = {525},
    year = {2011},
    publisher = {EMBO Press}
  }
  

• A. Drong , G. Nicholson , M. Schuster , F. Karpe , M. McCarthy , C. Holmes , M. Rantalainen , C. Lindgren , M. Consortia , The presence of methylation quantitative trait loci indicate a direct genetic influence on the level of methylation in adipose tissue, 2011.
  

  @inproceedings{drong2011presence,
    title = {The presence of methylation quantitative trait loci indicate a direct genetic influence on the level of methylation in adipose tissue},
    author = {Drong, A and Nicholson, G and Schuster, M and Karpe, F and McCarthy, MI and Holmes, CC and Rantalainen, M and Lindgren, CM and Consortia, M},
    year = {2011}
  }
  

2010

• M. Rantalainen , B. Herrera , G. Nicholson , Q. Wills , R. Bowden , M. Neville , J. Randall , A. Barrett , M. Allen , M. McCarthy , . others , Micro-ribonucleic acid expression profiling and expression quantitative trait loci analysis in human gluteal and abdominal adipose tissue, 2010.
  

  @inproceedings{rantalainen2010micro,
    title = {Micro-ribonucleic acid expression profiling and expression quantitative trait loci analysis in human gluteal and abdominal adipose tissue},
    author = {Rantalainen, M and Herrera, BM and Nicholson, G and Wills, QF and Bowden, R and Neville, MJ and Randall, JC and Barrett, A and Allen, M and McCarthy, MI and others},
    year = {2010}
  }